Optical Topography

• Compact, mobile and user-friendly
  A highly portable, compact and light unit which is easy to wheel up to the bedside or around a clinic. It has an extremely user friendly and efficient on-screen interface and rapidly generates accurate test results.
• Simultaneous multi-channel measurement
  A wide range of probes and holders enable a variety of assessments. This system can be configured to simultaneously take 24, 48 or 52 channel measurements.
• Live, non-invasive measurement with little or no patient restraint.
  Just place the sensor on the scalp while the optical topographer captures and measures real time images of live brain activity.

• Measurement channels:
  Available in 24 and 48 channel configurations. 52 channels can be measured with an optional 3x11 probe.
• Measurements:
  Changes in oxy-hemoglobin, deoxy-hemoglobin and total hemoglobin concentrations.
• Light source:
  Laser diodes of two wavelengths (695nm and 830 nm) measure oxy- and deoxy-hemoglobin simultaneously. The shorter wavelength light source enables multi-faced measurements with very low levels of background noise.
• Display format:
  Time-course graph display, 2D topographic images and mapped displays.
• Data sampling rate:
  10 samples per second.
• Interface:
  RS232 and BNC for external trigger and signal input/output.
• Network:
  LAN compatible for data sharing.
• Data format:
  Measurement data can be generated in text or Excel compatible files. Topographic images are available in BMP or AVI formats.

The ETG-4000 was engineered for ease of use in clinical and research environments. Possible fields of application include neuroscience, psychology, psychiatry, neonatology and education.

• Motor tasks.
  
• Speech recognition studies.
  
• Visual stimulation.
  
• Psychiatric disorders including depression and schizophrenia.
  
• Effects of aging (dementia) – development of preventive diagnostics.
  
• Neonatal – early detection of difficulties including audio sense, speech and visual.
  
• Pediatric – learning difficulties including ADHD and mental retardation.
  
• Language lateralization – assessment of hemispheric dominance for language before surgery (alternative to Wada test).
  
• Seizures – detection before surgery (epilepsy).
  
• Stroke assessment and rehabilitation
  

The research in functional near-infrared spectroscopy (fNIRS) is growing worldwide. Here are some recently published papers by European users of Hitachi Optical Topography systems.

Enhancement of Activity of the Primary Visual Cortex During Processing of Emotional Stimuli as Measured With Event-Related Functional Near-Infrared Spectroscopy and Event-Related Potentials

Keywords: emotion; EPN

Herrmann, Huter, Plichta, Ehlis, Alpers, Muehlberger, Fallgatte
University of Wuerzburg

Human Brain Mapping 28 (2007)



Event-Related Functional Near-Infrared Spectroscopy (fNIRS) Based on Craniocerebral Correlations: Reproducibility of Activation?

Keywords: restest reliability, reproducibility, event related, motor task

Plichta, Herrmann, Baehne, Ehlis, Richter, Pauli, Fallgatter
University of Wuerzburg

Human Brain Mapping 28:733-741 (2007)



Model-based analysis of rapid event-related functional near-infrared spectroscopy data: a parametric validation study

Keywords: time-series-analysis, GLM, Two-stage ordinary lease square, OLS, parametric design

Plichta, Heinzel, Ehlis, Pauli, Fallgatter
University of Wuerzburg

NeuroImage 35 (2007) 625-634



Cerebral oxygenation changes in the prefrontal cortex: Effects of age and gender

Keywords: sex, aging, verbal fluency task

Herrmann, Walter, Ehlis, Fallgatter
University of Wuerzburg

Neurobiology of Aging 27 (2006) 888-894



Event-Related Visual versus Blocked Motor Task: Detection of Specific Cortical Activation Patterns with Functional Near-Infrared Spectroscopy

Keywords: event related visual stimulation, motor stimulation

Plichta, Herrmann, Ehlis, Baehne, Richter, Fallgatter
University of Wuerzburg

Neuropsychobiology 2006; 57:77-82



Event-related functional near-infrared spectroscopy (fNIRS): Are the measurements reliable?

Keywords: vent related, reproducibility, test- retest reliability, time series analysis

Plichta, Herrmann, Baehne, Ehlis, Richter, Pauli, Fallgatter
University of Wuerzburg

NeuroImage 31 (2006) 116 – 124



OT during a Go-NoGo task assessed with multi-channel near-infrared spectroscopy

Keywords: prefrontal, CPT, response inhibition

Herrmann, Plichta, Ehlis, Fallgatter
University of Wuerzburg

Behavioural Brain Research 160 (2005) 135-140



Near infrared optical topography to assess activation of the parietal cortex during a visuo-spatial task

Keywords: Pariental cortex, line orientation, brain activity

Herrmann, Ehlis, Wagener, Jacob, Fallgater
University of Wuerzburg

Neuropsychologia 43 (2005) 1713-1720



Optical Topography with Near-Infrared Spectroscopy During a Verbal-Fluency Task

Keywords: VFT, cognitive activation

Herrmann, Ehlis, Scheuerpflug, Fallgatter
University of Wuerzburg

Journal of Psychophysiology 2005; Vol.19(2):100-105



Multi-channel near-infrared spectroscopy detects specific inferior-frontal activation during incongruent Stroop trials

Keywords: Stroop task, cognitive interference

Ehlis, Herrmann, Wagener, Fallgatter
University of Wuerzburg

Biological Psychology 69 (2005) 315-331



Towards a standard analysis for functional near infrared imaging

Keywords: general liner model, spectral analysis, visual stimulation

Schroeter, Bücheler, Müller, Uludag, Obrig, Lohmann, Tittgemeyer, Villringer, v.Cramon
Max-Planck Institute, Leipzig

Neuroimage 21 (2004) 283-290



Sounds and Silence: An optical topography study of language recognition at birth

Keywords: left hemisphere dominance, neonates, forward speech, backward speech

Pena, Maki, Kovacic, Dehaene-Lambertz, Koizumi, Bouquet, Mehler
International School for Advanced Studies, Trieste

PNAS 2003, vol.100, no.20 11702-11705